Nucleic acids in chemistry and biology pdf

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nucleic acids in chemistry and biology pdf

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Last reviewed: November An acidic, chainlike biological macromolecule consisting of multiple repeated units of phosphoric acid, sugar, and purine and pyrimidine bases. Nucleic acids Fig.

Chemical Biology of Nucleic Acids

Nucleic acids are the biopolymers , or large biomolecules , essential to all known forms of life. They are composed of nucleotides , which are the monomers made of three components: a 5-carbon sugar , a phosphate group and a nitrogenous base. If the sugar is a compound ribose , the polymer is RNA ribonucleic acid ; if the sugar is derived from ribose as deoxyribose , the polymer is DNA deoxyribonucleic acid. Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells. They play an especially important role in directing protein synthesis.

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Nucleic acid

Vester, L. Lundberg, M. Babu, S. Douthwaite, J. Biochem Soc Trans 1 February ; 32 1 : 37— DNAzymes consist of two binding arms that hybridize to a predetermined RNA sequence and a catalytic core that cleaves a phosphodiester bond held between the binding arms. DNAzymes are exemplified by the well-studied DNAzyme, which compared with protein ribonucleases is highly specific, albeit slow.

A free online book on the chemistry and biology of nucleic acids, written by Prof. The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab. Contact us About us Privacy policy Terms and conditions Legal information. Oligo synthesis custom oligonucleotides Research and development About us who we are Book on nucleic acids Oligo calculator oligonucleotide properties. Nucleic Acids Book A free online book on the chemistry and biology of nucleic acids, written by Prof.

Principles of Nucleic Acid Structure

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations roll, slide, twist, buckle, etc. This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. This handy guide ends with a complete list of resources, including relevant online databases and software.

Chemical Biology of Nucleic Acids

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology.

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